Ingredients

BACKED BY SCIENCE

14 Scientifically-Backed Ingredients

Fertient™ Men contains 14 essential amino acids, antioxidants, minerals, and vitamins, which are supported by more than 39 scientific researches about the effectiveness in optimizing sperm count, motility, morphology, and DNA fragmentation.

Lycopene - Fertient™ Men

Lycopene

Antioxidant
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Lycopene

Lycopene is a red pigment compound which is highly beneficial to support male fertility. Studies show that it can boost sperm count up to 70% as well as conferring advantages on the male reproductive system.

Lycopene contains antioxidant effects which can improve the sperm shape, sperm count, and sperm motility – it can react with free radicals and can decrease the incidence of oxidative stress.
Maca Extract - Fertient™ Men

Maca Extract

Antioxidant, Mineral
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Maca

Studies shows that Maca can affect the key hormone and can improve the function of reproduction without covering hormones. It is a type of wisdom which can understand what hormones need to balance and which to decrease or increase.

Men who are going to use Maca will experience a positive effect on libido and healthy sperm. Maca has enriched a number of vitamins and minerals which are necessary to conceive. This high nutritional profile compound has the ability to provide enough energy which can cause fertility.
L-Carnitine- Fertient™ Men

L-Carnitine

Amino Acid
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L-Carnitine

Use of L-Carnitine can support sperm motility. This compound is a potent antioxidant which can help in protecting sperm from free radical damage which has the ability to harm healthy sperm. Use of L-Carnitine can interfere with healthy DNA and can make conception better.

It is also an amino acid responsible which can provide cells enough energy including sperm cells. The use of this compound has the ability to normalize sperm motility. The men who are suffering from low sperm quality can get benefit from L-Carnitine with ease.
L-Arginine - Fertient™ Men

L-Arginine

Amino Acid
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L-Arginine

L-Arginine contains adequate quantity of amino acid which is essential to sperm production. A lot of research results show that proper supplementation of L-Arginine can increase sperm count and sperm motility. The components which are required to produce sperm can be provided by L-Arginine.
NAC - Fertient™ Men

N-Acetyl Cysteine

Amino Acids, Antioxidant
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N-Acetyl Cysteine (NAC)

NAC is one of many amino acids that is converted into cysteine which is a precursor of glutathione. So, Glutathione is naturally made in the body and is a powerful antioxidant that neutralizes certain reactive oxygen species (ROS).This aids in preventing free-radical damage to cell membranes and cells. Glutathione specifically reduces Hypochlorous Acid and Hydroxyl Radicals. This is important for sperm survival. As Glutathione reduces free radicals it improves the motility of sperm.
ALA - Fertient™ Men

Alpha Lipoic Acid

Antioxidant
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Alpha Lipoic Acid (ALA)

ALA is well known for its free radical scavenging ability. ALA is soluble in both fat and water, so it can protect both areas. Its ability to reduce oxidative stress increases sperm motility as well as reduce DNA fragmentation.

Free radicals are reduced in the mitochondria in the tail of the sperm allowing it work efficiently. Mitochondria produce energy in the form of ATP that drives tail locomotion and hence motility. Free radicals are also reduced in the nucleus where DNA is housed. This decreases DNA attack by free radicals preventing fragmentation.
Grape Seed Extract - Fertient™ Men

Grape Seed Extract

Antioxidant
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Grape Seed Extract (GSE)

GSE contains a healthy variety of antioxidants which are important to improve semen quality. The use of GSE on a continuous basis has the ability to affect sperm motility and sperm damage in a positive way. GSE contains natural antioxidants, such as Proanthocyanidins which can support sperm morphology and sperm DNA fragmentation.

Use of GSE has a positive impact to protect your body against oxidative stress. Grapes seeds are a natural element which is being extracted naturally from the plant which has plenty of nutritious benefits.
Selenium - Fertient™ Men

Selenium

Antioxidant, Mineral
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Selenium

Selenium has anti-oxidant activity aiding in eliminating oxidative stress which protects cells and cell membranes. A selenium deficiency is known to be involved with male infertility. It is involved with the production of sperm cells (spermatogenesis).

A lack of selenium in testicular tissue brings about the degeneration of sperm which ends in impairment of sperm motility. The major selenoprotein expressed in spermatozoa in the testes is known as phospholipid glutathione hydroperoxides (PHGPx) which has multiple functions with sperm quality and fertility.
Zinc - Fertient™ Men

Zinc

Mineral
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Zinc

Zinc is important for sperm germination, sperm quality, and fertilization. It carries antioxidant properties that decrease reactive oxygen species to prevent sperm membrane and intracellular damage. It’s important for balancing hormones such as testosterone important for sperm maturation.

It also has antibacterial properties that keep the male urinary system healthy. Zinc is essential for keeping the lining of the reproductive organs healthy and is involved with capacitation and acrosome reaction. Zinc deficiencies impair spermatogenesis.
Folic Acid - Fertient™ Men

Folic Acid

Vitamin
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Folic Acid

An important molecule for protecting cells from oxidative stress during sperm production is Homocysteine. Homocysteine’s production in the body is dependent on the availability of B vitamins and in particular folic acid (also known as B9).

Usually, free radicals and antioxidants balance each other out in the male reproductive system but during sperm generation, the mitochondria produce excess free radicals. At that time, an overproduction of free radicals is produced in semen and this has been demonstrated to increase sperm DNA fragmentation.
Vitamin A - Fertient™ Men

Vitamin A

Vitamin
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Vitamin A

Vitamin A (Beta carotene) is a powerful antioxidant that is converted into vitamin A in the body. This occurs when liver levels of vitamin A are low. It neutralizes free radicals preventing oxidative damage to cells. It is fat-soluble so it protects cell membranes and lipoproteins.

It is known for its ability to enhance sperm motility. This allows mitochondria inside the cell to function more efficiently to produce ATP from glucose. It also protects DNA from oxidative damage preventing fragmentation.
Vitamin B12 - Fertient™ Men

Vitamin B12

Vitamin
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Vitamin B12

Vitamin B12 is believed to improve semen quality . Semen quality is increased due to an increase in sperm count, sperm motility and a reduction in DNA fragmentation. This comes about due to improved reproductive function, a decrease in homocysteine toxicity, oxidative stress, nitric oxide production, and energy generated by spermatozoa & a decrease in inflammation in semen.

The idea is that high levels of B12 increase metabolism and provides more substances to make sperm, and increase in red blood cells provides more oxygen which improves overall fertility.
Vitamin C - Fertient™ Men

Vitamin C

Vitamin
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Vitamin C

Vitamin C is a powerful water-soluble antioxidant that helps to protect all cells from oxidative stress. It is known that vitamin C can improve sperm concentration, motility while decreasing the number of abnormal/deformed sperm cells. This is due to its scavenging of reactive oxygen species (ROS) which damage sperm cell membranes and sperm cells internally.

Vitamin E

Vitamin
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Vitamin E

Vitamin E is a powerful antioxidant that is fat-soluble and it has amphipathic properties due to its hydroxyl group (meaning it is partially soluble in water as well). This vitamin is able to interact with lipoproteins and cell membranes including sperm cell membranes.

There, vitamin E helps to protect fats in the membrane from free radicals damage. As vitamin E protects sperm membranes from reactive oxygen species, it protects sperm DNA from fragmentation because of the decrease in free radicals.

HOW IT HELPS

Usage At A Glance

Each ingredient has a different role in optimizing your overall sperm health. From sperm count, motility, morphology, to DNA fragmentation. Here is a summary of the usage of ingredients and the related researches.

Sperm Count Sperm Motility Sperm Morphology Sperm DNA Fragmentation
Lycopene

Yes(10)

Yes(11)

Yes(10,11,29)

Yes(9,28)

Maca Extract

Yes(3,4,5)

Yes(3,4,5)

Yes(3,4,5)

L-Carnitine

Yes(20,23,24)

Yes(22,24,31)

L-Arginine

Yes(33)

Yes(33,34)

Yes(33)

N-Acetyl Cysteine

Yes(13,14)

Yes(12,13,14)

Yes(13,14)

Yes(13)

Alpha Lipoic Acid

Yes(1)

Yes(1,2)

Yes(2)

Grape Seed Extract

Yes(31)

Yes(31)

Selenium

Yes(14,15)

Yes(14,15,16)

Yes(14,15,16)

Yes(27)

Zinc

Yes(6,7,8,17,19,30)

Yes(8,17,19,26)

Yes(17)

Yes(26,27)

Folic Acid

Yes(30)

Yes(39)

Yes(39)

Vitamin A

Yes(29)

Yes(27,28)

Vitamin B12

Yes(35,36)

Yes(36)

Yes(37)

Vitamin C

Yes(25)

Yes(26)

Yes(25,26,27)

Vitamin E

Yes(18,25)

Yes(18,26)

Yes(25,26,27)

  • Sperm Count
  • Sperm Morphology
  • Sperm Motility
  • Sperm DNA Fragmentation
Ingredient
Lycopene

Yes(10)

Yes(11)

Yes(10,11,
29)

Yes(9,28)

Maca Extract

Yes(3,4,
5)

Yes(3,4,
5)

Yes(3,4,
5)

L-Carnitine

Yes(20,23,
24)

Yes(22,24,
31)

L-Arginine

Yes(33)

Yes(33,34)

Yes(33)

N-Acetyl Cysteine

Yes(13,14)

Yes(12,13, 14)

Yes(13,14)

Yes(13)

Alpha Lipoic Acid

Yes(1)

Yes(1,2)

Yes(2)

Grape Seed Extract

Yes(31)

Yes(31)

Selenium

Yes(14,15)

Yes(14,15, 16)

Yes(14,15, 16)

Yes(27)

Zinc

Yes(6,7, 8,17, 19,30)

Yes(8,17, 19,26)

Yes(17)

Yes(26,27)

Folic Acid

Yes(30)

Yes(39)

Yes(39)

Vitamin A

Yes(29)

Yes(27,28)

Vitamin B12

Yes(35,36)

Yes(36)

Yes(37)

Vitamin C

Yes(25)

Yes(26)

Yes(25,26, 27)

Vitamin E

Yes(18,25)

Yes(18,26)

Yes(25,26, 27)

1Haghighian, Hossein Khadem et al. “Randomized, triple-blind, placebo-controlled clinical trial examining the effects of alpha-lipoic acid supplement on the spermatogram and seminal oxidative stress in infertile men.” Fertility and sterility 104 2 (2015): 318-24 .
2Ibrahim, Siti Fatimah Binti et al. “A Study of the Antioxidant Effect of Alpha Lipoic Acids on Sperm Quality.” Clinics (2008).
3Melnikovova, Ingrid et al. “Effect of Lepidium meyenii Walp. on Semen Parameters and Serum Hormone Levels in Healthy Adult Men: A Double-Blind, Randomized, Placebo-Controlled Pilot Study.” Evidence-based complementary and alternative medicine : eCAM vol. 2015 (2015): 324369. doi:10.1155/2015/324369
4Ingrid Melnikovova, Tomas Fait, Michaela Kolarova, Eloy C. Fernandez, and Luigi Milella, “Effect of Lepidium meyenii Walp. on Semen Parameters and Serum Hormone Levels in Healthy Adult Men: A Double-Blind, Randomized, Placebo-Controlled Pilot Study.” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 324369, 6 pages, 2015.
5Gonzales, Gustavo & Cordova, Amanda & Gonzales, Carla & Chung, A & Vega, Karen & Villena, Arturo. (2002). Lepidium meyenii (Maca) improved semen parameters in adult men. Asian journal of andrology. 3. 301-3.
6Mankad M, Sathawara N, Doshi H, Saiyed H, Kumar S. Seminal plasma zinc concentration and α-glucosidase activity with respect to semen quality. Biol Trace Elem Res. 2006;110(2):97–106.
7Liu DY, Sie BS, Liu ML, Agresta F, Baker HW. Relationship between seminal plasma zinc concentration and spermatozoa–zona pellucida binding and the ZP-induced acrosome reaction in subfertile men. Asian J Androl. 2009;11(4):499–507.
8Badade ZG, More K, Narshetty J. Oxidative stress adversely affects spermatogenesis in male infertility. Biomed Res. 2011;22(3):319–22.
9Devaraj S, Mathur S, Basu A, Aung HH, Vasu VT, et al. A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress. J Am Coll Nutr. 2008;27:267–73.
10Mohanty N, Kumar S, Jha A, Arora R. Management of idiopathic oligoasthenospermia with lycopene. Indian J Urol. 2001;18:57–61
11Gupta NP, Kumar R. Lycopene therapy in idiopathic male infertility–a preliminary report. Int Urol Nephrol. 2002;34:369–72.
12Ciftci, Halil, Ayhan Verit, Murat Savas, Ercan Yeni, and Ozcan Erel. “Effects of N -acetylcysteine on Semen Parameters and Oxidative/Antioxidant Status.” Urology 74.1 (2009): 73-76.
13Jannatifar, Rahil et al. “Effects of N-acetyl-cysteine supplementation on sperm quality, chromatin integrity and level of oxidative stress in infertile men.” Reproductive biology and endocrinology : RB&E vol. 17,1 24. 16 Feb. 2019, doi:10.1186/s12958-019-0468-9
14Safarinejad MR, Safarinejad S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol. 2009;181(2):741–751. doi: 10.1016/j.juro.2008.10.015.
15Mossa M M, Azzawi M H, Dekhel H H. Effect of Selenium in Treatment of Male Infertility. Exp Tech Urol Nephrol. 1(5). ETUN.000521. 2018.
16Moslemi, Mohammad K, and Samaneh Tavanbakhsh. “Selenium-vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate.” International journal of general medicine vol. 4 99-104. 23 Jan. 2011, doi:10.2147/IJGM.S16275
17Tikkiwal M., Ajmera R.L., Mathur N.K. Effect of zinc administration on seminal zinc and fertility of oligospermic males. Indian J. Physiol. Pharmacol. 1987;31:30–34.
18Suleiman S.A., Ali M.E., Zaki Z.M., el-Malik E.M., Nasr M.A. Lipid peroxidation and human sperm motility: Protective role of vitamin E. J. Androl. 1996;17:530–537.
19Omu A.E., Dashti H., Al-Othman S. Treatment of asthenozoospermia with zinc sulphate: Andrological, immunological and obstetric outcome. Eur. J. Obstet. Gynecol. Reprod. Biol. 1998;79:179–184. doi: 10.1016/S0301-2115(97)00262-5.
20Lenzi A, Lombardo F, Sgro P, Salacone P, Caponecchia L, Dondero F,Gandini L. Use of carnitine therapy in selected cases of male factor infertility: a double blind cross-over trial. Fertil Steril, 2003; 79: 292-300.
21Vicari E, La Vignera S, Calogero AE. Antioxidant treat-ment with carnitines is effective in infertile patients with prostato-vesiculo-epididymitis and elevated seminal leu-kocyte concentrations after treatment with nonsteroidal anti-inflammatory compounds. Fertil Steril 2002; 78: 1203-8.
22Zhou, Xin, Fang Liu, and Suo-Di Zhai. “Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review.” Asia Pacific journal of clinical nutrition 16.S1 (2007): 383-390.
23Costa, M., et al. “L‐carnitine in idiopathic asthenozoospermia: a multicenter study.” Andrologia 26.3 (1994): 155-159.
24Eidi, Maryam, et al. “Effect of L-carnitine supplement on semen parameters in men with idiopathic infertility.” Medical Science Journal of Islamic Azad Univesity-Tehran Medical Branch 19.1 (2009): 11-15.
25Kodama H, Yamaguchi R, Fukuda J, et al. Increased oxidative deoxyribonucleic acid damage in the spermatozoa of infertile male patients. Fertil Steril 1997
26Omu AE, Al-Azemi MK, Kehinde EO, et al. Indications of the mechanisms involved in improved sperm parameters by zinc therapy. Med Princ Pract 2008;17:108-16.
27Ménézo YJ, Hazout A, Panteix G, et al. Antioxidants to reduce sperm DNA fragmentation: an unexpected adverse effect. Reprod Biomed Online 2007;14:418-21.
28Ghyasvand, Taiebeh et al. “Serum levels of lycopene, beta-carotene, and retinol and their correlation with sperm DNA damage in normospermic and infertile men.” International journal of reproductive biomedicine (Yazd, Iran) vol. 13,12 (2015): 787-92.
29Zareba, Piotr et al. “Semen quality in relation to antioxidant intake in a healthy male population.” Fertility and sterility vol. 100,6 (2013): 1572-9. doi:10.1016/j.fertnstert.2013.08.032
30Wong, Wai Yee, et al. “Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial.” Fertility and sterility 77.3 (2002): 491-498.
31ala A.H., Khattab Z.A., Abdallah G., Kamel M. Grape seed extract alleviate reproductive toxicity caused by aluminium chloride in male rats. J. Am. Sci. 2010;6:352–361
32Soleimani, Mohammad & Masoumi, Navid. (2017). The Effect of Grape Seed Extract on Semen Oxidative Stress Markers in Men with Idiopathic Infertility- A Cross-Sectional Before-After Study. Nephro-Urology Monthly. In Press. 10.5812/numonthly.13837.
33Keller, David W., and Kenneth L. Polakoski. “L-arginine stimulation of human sperm motility in vitro.” Biology of reproduction 13.2 (1975): 154-157.
34Stanislavov R, Nikolova V, Rohdewald. Improvement of seminal parameters with Prelox: a randomized, double-blind, placebo-controlled, cross-over trial. Photother Res. 2009;23(3):297-302.
35Goodhope C.D. The treatment of oligospermia with stilbestrol and vitamin B. Fertil. Steril. 1961;12:469–473. doi: 10.1016/S0015-0282(16)34271-6.
36Isoyama R., Kawai S., Shimizu Y., Harada H., Takihara H., Baba Y., Sakatoku J. Clinical experience with methylcobalamin (CH3-B12) for male infertility. Hinyokika Kiyo. 1984;30:581–586.
37Gual-Frau J., Abad C., Amengual M.J., Hannaoui N., Checa M.A., Ribas-Maynou J., Lozano I., Nikolaou A., Benet J., Garcia-Peiro A., et al. Oral antioxidant treatment partly improves integrity of human sperm DNA in infertile grade Ivaricocele patients. Hum. Fertil. 2015;18:225–229. doi: 10.3109/14647273.2015.1050462.
38Sinclair S. Male infertility: Nutritional and environmental considerations. Altern. Med. Rev. 2000;5:28–38.
39Rarani, F.Z., Golshan-Iranpour, F. & Dashti, G.R. Cell Tissue Bank (2019) 20: 367. https://doi.org/10.1007/s10561-019-09775-6
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